O-specific polysaccharide responses and cholera

Laboratory surveillance - Vaccines Bangladesh - United States of America active

Project timeline: 01/09/2020 - 31/08/2025

Lead Researcher

Prof. Edward Ryan

Organisation / Institution

Harvard University, and Massachusetts General Hospital


NIH - National Institutes of Health

Project summary

This project focuses on defining O-specific polysaccharide (OSP) responses during cholera and development of vaccines protective against cholera and enteric infection.

Lay summary

Immune responses that mediate protection against cholera target the sugar (OSP) that coats the bacteria that causes cholera. Young children in particular do not develop high level or durable immune responses against this sugar after oral cholera vaccination. Understanding and improving these responses will be critical in development of next generation cholera vaccines that can protect young children against cholera, and that can be incorporated in EPI schedules.

Potential for public health impact or global health decision-making

Informs development of next generation cholera vaccines for use in children under 5 years of age.


Firdausi Qadri, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)

Key Collaborators

International Vaccine Institute, Seoul, South Korea