Effect of extended dose intervals on the immune response to oral cholera vaccine in Zambia

Laboratory surveillance - Vaccines Zambia completed

Project timeline: 07/12/2019 - 26/02/2021

Lead Researcher

Prof. David Sack

Organisation / Institution

Johns Hopkins Bloomberg School of Public Health


Bill & Melinda Gates Foundation

Project summary

This project will evaluate the vibriocidal responses following receipt of oral cholera vaccine (Shanchol) when the second dose is given either 2 weeks or 6 months following the first dose. The primary outcome is the change in geometric mean vibriocidal titers two weeks after the second dose, but additional serum samples will be obtained to determine longevity of the increased titers.

Potential for public health impact or global health decision-making

Assurance of a non-inferior vibriocidal response when the second dose of OCV is delayed will provide guidance for timing of the second dose.


Amanda Debes
John Mwamba
Roma Chilingi
Caroline Cleopatra Chisenga

Key Collaborators

Center for Infectious Disease Research in Zambia

Resources (1)


Serum vibriocidal responses when second doses of oral cholera vaccine are delayed 6 months in Zambia