Project timeline: 07/12/2019 - 26/02/2021
Prof. David Sack
Johns Hopkins Bloomberg School of Public Health
Bill & Melinda Gates Foundation
This project will evaluate the vibriocidal responses following receipt of oral cholera vaccine (Shanchol) when the second dose is given either 2 weeks or 6 months following the first dose. The primary outcome is the change in geometric mean vibriocidal titers two weeks after the second dose, but additional serum samples will be obtained to determine longevity of the increased titers.
Assurance of a non-inferior vibriocidal response when the second dose of OCV is delayed will provide guidance for timing of the second dose.
Caroline Cleopatra Chisenga
Center for Infectious Disease Research in Zambia