Adaptive Molecular Diagnostics

Laboratory surveillance India - Malawi - United Kingdom completed

Project timeline: 01/12/2020 - 30/11/2022

Lead Researcher

Dr. Ankur Mutreja

Organisation / Institution

University of Cambridge


Wellcome Trust

Project summary

Our project will use genomic data and a detailed understanding of pathogen evolution to deliver a robust, rapid, accurate and cost-effective pathogen detection kit for use in the field. Current methods are unsuitable for detection as they are slow, inaccurate and cannot be field deployed. Our work has already changed the basic understanding of how cholera spreads and identified high and low epidemic risks that are the cornerstones of disease prevention. By making robust molecular indicator kits adapted to field settings we are able to rapidly probe the likely behaviour of cholera strains and provide actionable data that can make a direct contribution to a major human health challenge.

Potential for public health impact or global health decision-making

This project will help fasten decision making in cholera outbreak control by indicating the risk associated with the type of cholera detected.


Nicholas Thomson
Sophie Palmer

Key Collaborators

NICED, India
RMRC, India
GMC, India
THSTI, India
RGCB, India
CMC, Vellore
MAHE, India
LSTM, Malawi